New research by a team of Israeli doctors commissioned by the United States Air Force finds that the popular anti-diabetes drug extendin-4 could have beneficial effects in the treatment of traumatic brain injury.
The research found that the diabetes drug minimized the severity of the injury in animals when the drug was administered soon after the injury. Extendin-4 has been approved by the Food and Drug Administration, and is designed primarily to control the sugar levels in the body. However, there has been some scientific research that has linked this drug with a host of benefits in the treatment of other conditions. For instance, extendin-4 is believed to have some beneficial effects in the treatment of Alzheimer’s disease.
As part of their research, the doctors designed a clinical experiment that involved lab mice. The mice were exposed to controlled explosions that were triggered between 23 and 33 feet away. The doctors analyzed the severity of the injuries and the effect of extendin-4 on treating these injuries.
There were 4 groups of mice. The first was a control group, while the 2nd group was exposed to the explosions without being administered the extendin-4. The 3rd group received extendin-4, but was not exposed to the explosions, while the last group was exposed to the blasts, and was given the medication within one hour after the injury. The last group was also continuously given extendin-4 for a period of 7 days after the injury.
An analysis of the results found that the mice that had been exposed to the explosions had suffered severe traumatic brain injury, compared to the control group in which the mice had not been exposed to the explosions. However, among the mice that had been exposed to the blasts, and had also been administered the extendin-4 therapy, the doctors found that the brain function was almost on par with those in the control group. This shows that the administration of extendin-4 significantly reduces the impairment of brain function seen in mice that were exposed to the explosions.
The researchers hope that this study will lead to the development of a combination of medications that can be used to help minimize the effects of a traumatic brain injury. Currently, most treatments that brain injury lawyers know of focus on reducing or limiting the impact of the injury, because there is no long-lasting cure for these injuries.
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